They can suggest ways to help relieve this side effect. For this purpose, Zetia may be used: The only FDA-approved dosage of Zetia is 10 mg once a day. Zetia is approved to treat certain forms of high cholesterol in children ages 10 years and older when used with a low-cholesterol diet. It can also interact with certain supplements as well as certain foods. As with most drugs, some people can have an allergic reaction after taking Zetia. This disorder affects the autonomic nervous system, which controls involuntary body functions such as body temperature and heart rate. The following information describes dosages that are commonly used or recommended. Some people may develop mild or serious side effects during Zetia treatment. Get emergency medical help if you have signs of an allergic reaction to Zetia: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Zetia may be used with statin drugs to treat the following conditions in adults: Statins are another class of medications used to lower cholesterol. This may increase your risk of side effects. The following lists contain some of the key side effects that may occur while taking Zetia. You may also be having a reaction to all the medications mixed together. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about . What are the more common side effects of Zetia? * To learn more about this side effect, see the Side effects explained section below. Statin drugs arent safe to use during pregnancy. This part of the nervous system controls functions that we don't actively control, such as heart rate, blood pressure, perspiration, and temperature. Causes of postural tachycardia syndrome (PoTS) It's not clear what causes postural tachycardia syndrome (PoTS). Porphyria patients are often overly sensitive to sunlight. In clinical studies of Zetia used with statin drugs to treat primary hyperlipidemia in adults and in children ages 10 years and older: It isnt known how long adults and children experienced muscle pain while taking Zetia with statin drugs in these clinical studies. For this purpose, Zetia is used with a low-cholesterol diet (but with no other drugs) in adults and in children ages 10 years and older. And some may be easily managed, too. This in turn increases clearance of cholesterol from the blood. Examples of other drugs that may be used to treat primary high cholesterol include: Examples of other drugs that may be used to treat mixed high cholesterol include: Examples of other drugs that may be used to treat homozygous familial hypercholesterolemia include: Examples of other drugs that may be used to treat homozygous sitosterolemia include: You may wonder how Zetia compares with other medications that are prescribed for similar uses. These symptoms could be life threatening and require immediate medical care. They may want to select a different treatment option for you. Talk with your doctor if youre concerned about your risk of memory loss while using Zetia alone or with a statin drug. If your doctor confirms you had a mild allergic reaction to Zetia, theyll decide if you should continue using it. You should store Zetia tablets at a room temperature of 77F (25C) in a tightly sealed container away from light. Zetia is FDA-approved to treat certain forms of high cholesterol in adults and children. Watch Part 2 here: https://youtu.be/HPfo2QOa89YHello Friends! This is not a complete list of side effects and others may occur. Total cholesterol consists of: High cholesterol occurs when you have more cholesterol in your blood than your body needs. Crossing your legs in front of each other while standing, rocking up and down on your toes. In Zetia's clinical studies, these were some of the side effects that occurred more often: pain in the arms or legs. Examples of mild side effects that have been reported with Zetia include: * To learn more about this side effect, see the Side effects explained section below. (Fenofibrate is a drug used to lower your triglyceride levels.). Learn about alternatives like new drugs, A new class of self-injectable medications are showing promise in treating high cholesterol. Covers lawsuits, malpractice, class actions, fraud, legislation, regulation, enforcement. This can raise your levels of these drugs and increase your risk of side effects. It can cause mild side effects and, less commonly, serious side effects. However, 0.3% of people who took Zetia alone experienced joint pain so bothersome that they had to stop treatment. * For more information about this side effect, see " Zetia: Side effects explained " below. Zetia generally costs more than Crestor. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia that is estimated to impact between 1,000,000 and 3,000,000 Americans, and millions more around the world. Clinical studies looked at Zetia for the treatment of primary hyperlipidemia in adults and in children ages 10 years and older. These lists contain examples of serious side effects that can occur with Lipitor or with both drugs (when taken individually). Zetia is FDA-approved to treat certain types of high cholesterol in adults and in children when used with a low-cholesterol diet. If youre taking a statin drug with Zetia, they may recommend that you take a supplement called coenzyme Q10 (CoQ10). A generic drug is an exact copy of the active drug in a brand-name medication. Currently, no medications have been approved by the FDA to treat POTS. Postural orthostatic tachycardia syndrome (POTS) is a form of dysautonomia, or a malfunction of the autonomic nervous system. Using Zetia with medications in the fibrate drug class raises your risk of gallstones even more. . Zetia shouldnt cause weight gain or weight loss. . Since every POTS patient is different, some may primarily experience gastrointestinal symptoms, such as nausea, vomiting or poor feeding, Berger explained. Lipitor ( atorvastatin) and Zetia ( ezetimibe) are used to lower cholesterol levels in the blood. Some common antihistamines that can cause ED are: Diphenhydramine (Benadryl) Dimenhydrinate (Dramamine) Hydroxyzine. No, clinical studies havent shown Zetia to affect blood pressure. Despite having lower total cholesterol than white people, African Americans are at greater risk of dying from heart disease. For most people, CoQ10 isnt a harmful or dangerous supplement. Off-label use is when a drug thats approved to treat one condition is used to treat a different condition. Zetia is metabolized in the small intestine and liver. Some people experience mild side effects with Zetia. They can give you tips on how to deal with any side effects that may be bothersome. Another is trouble standing up, primarily because not enough blood returns to the heart upon standing, which causes a rapid increase in heart rate called tachycardia. For this purpose, Zetia may be used alone or with fenofibrate. The side effects from Zetia .. muscle weakness, joint pain, upper respiratory infectikns resemble the symptoms of malabsorption of Vitamin A,D, E and K. Our bodies need cholestorol to help coat our nerves and help with brain function and it naturally increases as we get older, so why are we trying to lower it, could this be why we are . Clinical studies have shown Zetia to be effective for treating primary high cholesterol when used alone or with statin drugs. Drugs in this class prevent your small intestine from absorbing cholesterol. Sharing this information can help you avoid potential interactions. diarrhea. * Zetia is also approved to treat these conditions in children ages 10 years and older. Memory loss isnt a side effect of Zetia. Your doctor may stop your Zetia treatment if it isnt safe or effective for you. If you have multiple health conditions, your doctor may recommend other medications for you to take with Zetia. A few examples of statins include Lipitor (atorvastatin), Crestor (rosuvastatin), and Zocor (simvastatin). If left untreated, it can cause your kidneys to stop working properly. Zetia does not cause an increase or a decrease in blood pressure. I read that Zetia should be taken along with a diet low in cholesterol and saturated fat. Also, Zetia use may cause increased liver enzyme levels, especially if its taken with a statin drug. Ways to reduce the symptoms. A large review by the American Heart Association compared studies of CoQ10. Created for people with ongoing healthcare needs but benefits everyone. Bethenny Frankel is opening up about her health issue, explaining to her Instagram followers about her battle with postural orthostatic tachycardia syndrome (POTS) after receiving comments about the change in her physical appearance. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Bock's fainting spells are one of the hallmarks of POTS. The bottom line: Zetia may cause fewer side effects than statins (though some clinicians might dispute that) but Zetia may cause muscle problems and other adverse reactions. What causes POTS? Zetia reduces the buildup of fats, cholesterol, and other substances on the artery walls (this process is known as atherosclerosis) and if taken long term it may reduce the risk of heart disease. Symptoms of atherosclerosis may include confusion, fatigue (lack of energy), trouble breathing, or pain in your chest, arms, or legs. Zetia is approved to treat certain forms of high cholesterol in adults when used with a low-cholesterol diet. Some side effects are more common than others. To determine whether you have high cholesterol, your doctor will do a blood test called a lipid panel. When taken together, it should be administered at least 2 hours before or 4 hours after a bile acid sequestrant. For example, in studies, some people had to stop taking the drug because their liver enzyme levels increased. If your cholesterol levels havent started to improve, they may recommend a different treatment for you. (A class of drugs is a group of medications that work in a similar way.) Eating large meals can worsen hypotension in some individuals with dysautonomia (Mathias, 2000). The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. These side effects may be temporary, lasting a few days to weeks. Zetia (ezetimibe) is a prescription drug used to treat certain types of high cholesterol in adults and children. Zetia may not be right for you if you have certain medical conditions or other factors affecting your health. In these studies, 12 weeks of treatment with Zetia and fenofibrate was compared with Zetia taken alone, fenofibrate taken alone, or a placebo (a treatment with no active drug). Statins, another medication for high cholesterol, are known to cause muscle-related side effects. This helps prevent others, including children and pets, from taking the drug by accident. Below are medications that can interact with Zetia. If youre currently taking cyclosporine, talk with your doctor about whether its safe for you to take Zetia. However, 0.5% of adults and children who took Zetia with a statin drug experienced muscle pain so bothersome that they had to stop treatment. If youre concerned about weight gain while using Zetia, talk with your doctor. Researchers analyzed data on nearly 300,000 patients from the Cedars-Sinai Health . In addition to Goff's specific symptoms, POTS can be associated with neurocognitive impairments or "brain fog"; problems with body temperature regulation; gastroenterological symptoms like nausea, abdominal pain, diarrhea, or constipation; and dark red-blue discoloration of the legs. Energy Drinks, such as Red Bull, should be avoided in those with POTS. When you get Zetia from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This means you should avoid foods that are high in cholesterol and other types of fat. OI is a condition in which an excessively reduced volume of blood returns to the heart after an individual stands up from a lying down position. Zetia may not be right for you if you have certain medical conditions or other factors that affect your health. Others may experience GI issues in conjunction with other symptoms, such as fainting. Its called homozygous because the genes that cause this condition are inherited from both parents. Here is a list of conditions that the Food and Drug Administration (FDA) has approved Zetia and Crestor to treat. Call your doctor right away if you have serious side effects. Have your doctor measure your heart rate sitting and standing. Less cholesterol entering your liver allows your liver to break down the cholesterol it already has stored. What foods should I avoid while taking Zetia. Theyll guide you on the safest treatment options for you. Below are examples of these side effects. 5.8k views Answered >2 years ago. The expiration date helps guarantee that the medication is effective during this time. The most common side effects of Zetia include: muscle or joint pain, (2018). Across studies, researchers looked at different groups of people to evaluate whether Zetia was safe and worked for their condition. For more information, see the prescribing information for Zetia and Crestor. Zetia is meant to be used as a long-term treatment. If you have side effects of Zetia that bother you, talk with your doctor or pharmacist. Zetia is contraindicated under the following conditions: Zetia tablets should be stored at a room temperature of 77F (25C) in a tightly sealed container away from light. Specifically, Zetia is used along with a low-cholesterol diet to treat: Zetia is approved to treat these conditions in certain situations. Phase IV trials are used to detect adverse drug . Sometimes doctors will recommend taking both a statin medication and Zetia for high cholesterol. However, be sure to take the dosage your doctor prescribes for you. If you drink alcohol and have questions about drinking it during Zetia treatment, talk with your doctor. Statins lower cholesterol by preventing your liver from making new cholesterol. Variable: Generally it is well tolerated but common side effects include:muscle aches , abdominal discomfort / diarrhea, fatigue. See the Mild side effects and Serious side effects sections above for more information. This is because large meals can cause blood to pool excessively in the abdomen. Brain fog. In clinical studies, Zetia has been found to be effective for treating mixed high cholesterol when used with fenofibrate. There arent any foods that have been specifically reported to interact with Zetia. However, you may need to avoid grapefruit if you take Zetia with a statin, another type of cholesterol medication. Brand-name medications usually cost more than generics. If you miss a dose of Zetia, you can take your missed dose as soon as you remember. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Doing this can raise your risk of side effects. Typical symptoms of POTS include: heart palpitations (feeling your heart beating or racing) dizziness or lightheadedness. However, your doctor will check your cholesterol levels about 4 weeks after you start treatment. Twelve weeks of treatment with Zetia and atorvastatin or simvastatin was compared with atorvastatin or simvastatin used alone. A Mayo Clinic study published this month in Pacing and Electrophysiology (PACE), suggests that a class of medications more commonly prescribed for older adults is a strong first-line treatment for teenagers with a debilitating condition called postural orthostatic tachycardia syndrome, or POTS. 2. sinusitis. Zetia contains the active drug ezetimibe. Talk with your doctor or pharmacist if you have trouble swallowing Zetia tablets. If youve had an allergic reaction to Zetia or any of its ingredients, you should not take Zetia. Postural orthostatic tachycardia syndrome (POTS) is a blood circulation disorder characterized by two factors: A specific group of symptoms that frequently occur when standing upright. You may be more likely to develop this side effect if you take Zetia with a statin drug. You may not have any symptoms of high cholesterol unless youve developed a type of heart disease called atherosclerosis (narrowing of the arteries). Its primary metabolic pathway is via hepatic glucuronic conjunction. These lists dont include all possible side effects. POTS is a form of "autonomic dysregulation" (a nervous system disorder) in which your heart rate spikes upon standing (among other symptoms). For more information, see the Precautions section below. Crestor is part of the statin drug class. Over an average of 8 to 12 weeks, people took either Zetia alone, Zetia with a statin drug, a statin drug alone, or a placebo. Generics tend to cost less than brand-name drugs. Zetia is also used to reduce blood levels of fats called plant sterols in people with homozygous sitosterolemia. These conditions can raise your risk of muscle problems while taking Zetia. If you have questions about the differences between Zetia and statin drugs, talk with your doctor. Side effects could occur in children who are breastfed by someone taking a statin drug. These drugs havent been directly compared in clinical studies. You can learn more about how we ensure our content is accurate and current by reading our. Then theyll monitor whether the drug is working for you and whether you experience any side effects. They may have a preference for one version or the other. You can use the study as a second opinion to make health care decisions. Zetia is a lipid-lowering compound used to treat high cholesterol.Common side effects of ezetimibe include diarrhea, abdominal pain, back pain, joint pain, muscle aches, and sinus infection ().. Serious side effects of ezetimibe include hypersensitivity reactions (including angioedema - swelling of the skin and underlying tissues of the head and neck - that can be life-threatening), skin rash . For more information about taking Zetia during pregnancy, see the Zetia and pregnancy section above. This drug has not been studied in pregnant females.*. upper respiratory tract infection, including the common cold. pain in your arms or legs. Cardiology 33 years experience. joint or muscle pain*. Its not known if Zetia is safe to take during pregnancy. An increase in levels of liver enzymes doesnt usually cause any symptoms. Learn about side effects, dosage, and more. Statins are another type of medication used to lower cholesterol. If your liver function tests show increased liver enzymes called transaminases while youre using Zetia with a statin drug, your doctor may stop your treatment. Postural orthostatic tachycardia syndrome (POTS) is a condition that causes a number of symptoms when you transition from lying down to standing up, such as a fast heart rate, dizziness and fatigue. Zetia is approved to treat different types of high cholesterol. This is because it isnt safe to eat grapefruit or drink grapefruit juice while using a statin. But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Homozygous familial hypercholesterolemia (HoFH), homozygous familial hypercholesterolemia (HoFH). Examples of bile acid sequestrants include: Zetia inhibits the intestinal absorption of cholesterol and phytosterols, resulting in a decrease in the transport of intestinal cholesterol to the liver. Your body uses cholesterol to make some vitamins, hormones, and fluids that help you digest food. Below are examples of these side effects. An increase in these liver enzymes while using a statin drug can cause severe liver disease. It also isnt known what percentage of adults and children experienced diarrhea in clinical studies of other conditions treated with Zetia. And do not stop using Zetia unless your doctor recommends it. You can take Zetia at any time during the day, but try to take your dose around the same time each day. Zetia generally costs less than Lipitor. Zetia may cause serious side effects including: muscle pain, muscle tenderness or weakness, fever, unusual tiredness, and. Statins are cholesterol drugs that may be taken with Zetia. These problems can include muscle pain and muscle weakness, and rarely, muscle breakdown. Over time, plant sterols can build up in your blood vessels and raise your risk of heart disease. Postural Tachycardia Syndrome (PoTS) is an abnormality of the autonomic nervous system (ANS). Chylomicrons help your body, low-density lipoproteins (LDL), sometimes referred to as bad cholesterol, high-density lipoproteins (HDL), sometimes referred to as good cholesterol, triglycerides, which are a type of fat that are building blocks of cholesterol, Apo B (high levels of this protein are a sign of high cholesterol), non-HDL cholesterol (calculated by subtracting your HDL cholesterol level from your total cholesterol), were reduced by an average of 13% to 14% in people who used Zetia, ranged from not changing to being reduced by an average of 1% in people who used a placebo, were reduced by an average of 18% in people who used Zetia, increased by an average of 1% in people who used a placebo, decreased by an average of 13% to 14% in people who used Zetia alone, decreased by an average of 15% to 40% in people who used a statin alone, depending on the statin used, decreased by an average of 24% to 46% in people who used Zetia and a statin, depending on the statin used, ranged from decreasing by an average to 1% to increasing by an average of 4% in people who took a placebo, decreased by an average of 19% to 20% in people who used Zetia alone, decreased by an average of 20% to 54% in people who used a statin alone, depending on the statin used, decreased by an average of 34% to 61% in people who used Zetia and a statin, depending on the statin used. What Are the Injectable Alternatives to Statins? They can both be taken with or without food. So if youre taking Zetia with a statin drug, you may need to avoid eating grapefruit or drinking grapefruit juice during your treatment. If you develop bothersome muscle pain or other muscle-related symptoms, talk with your doctor. They may have suggestions depending on your weight and health goals. If you and your doctor decide that Zetia treatment isnt right for you, you simply wont take any more doses. If your doctor recommends that you stop taking Zetia, they may suggest another treatment option for your condition. This date is typically 1 year from the date they dispensed the medication. LDL cholesterol was reduced by 15% more in children who took Zetia and simvastatin than in children who took simvastatin alone. Read more about how inherited high cholesterol affects life expectancy and what makes it different from regular hypercholesterolemia. Physicians who treat dysautonomia can be located on our Physician List. For instance, some interactions can interfere with how well a drug works. Phil Fischer, M.D., medical director of Mayo Clinic's children's hospital and a POTS specialist, led . The list below includes factors to consider. unusual tiredness or weakness. Zetia is primarily cleared from the body through fecal excretion. Zetia is a prescription drug used to treat certain types of high cholesterol. Tell them about all prescription, over-the-counter, and other drugs you take. The generic is considered to be as safe and effective as the original drug. Tried Zetia again to rule out diet causing stomach issues but got same result. The children took Zetia and simvastatin or simvastatin alone. During your Zetia treatment, consider keeping notes on any side effects youre having. Zetia should be protected from moisture and shouldnt be stored in areas where it could get damp or wet, such as bathrooms. Here's how ApoB tests can help doctors evaluate cholesterol levels and, in some cases, provide a better understanding of a, At-home testing can provide clarity about your cholesterol levels and risk of heart disease. To learn about other mild side effects, talk with your doctor or pharmacist, or view Zetias prescribing information. Allergic reaction. Cholesterol is a fatty substance found in the cells of your body. Ezetimibe can cause the breakdown of muscle tissue . Any time youre considering taking a supplement, its important to discuss this with your doctor or pharmacist. Your doctor will likely start you on the typical dosage approved to treat your condition. They are caused by deficiencies in enzymes involved in the synthesis of heme. Drug Administration ( FDA ) has approved Zetia and pregnancy section above FDA-approved dosage of Zetia that bother,. Mg once a day tolerated but common side effects explained section below while standing, rocking and. 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